state-of-the-art medical imaging software solutions

Renogram

Hermes Hybrid Viewer™ NM Processing Renogram

The HERMES Renogram Analysis Program (REN™) is designed to calculate a number of renal function parameters, including relative perfusion, relative function, transit times and outflow efficiency.

• Flexible and configurable renal analysis
• User designed final display
• Wide choice of parameters & published methods

 

The HERMES Renogram Analysis Program is designed to calculate a number of renal function parameters, including relative perfusion, relative function, transit times and outflow efficiency.
The relative function may be calculated from Patlak plots (8,9,11), or from the uptake slope of the renogram curves, or from the integral of the renogram curves over a defined time period.
The program can display the retention function curves of the two kidneys and the parenchymal regions, and calculate the relative perfusion and function from
the retention functions as well as the minimum, mean and maximum transit times (2,4,6).
The program can display the outflow curves for both kidneys and the value of the outflow at any selected time (1).
The program can also be used to calculate parameters used in the assessment of kidney transplants (7).

 

Summary of features

• Choice of methods of analysis
• Automatic or manual kidney and parenchymal region definition on several images simultaneously
• Optional attenuation correction
• Background region positions and size can be selected by the user
• Functional images of time to maximum and maximum counts
• Option to display aligned and normalised post-micturition image
• Final display of curves, images and numerical results can be customised by the user

Quantitative Results

• Relative perfusion from integral and retention function curves
• Relative uptake function from Patlak, integral, uptake slope, retention function curves
• Outflow efficiency index
• Minimum, mean and maximum transit times for whole kidney and parenchyma
• Time to maximum and residual cortical activity
• Renal clearance
• Uptake capacity, tubular transit index, and perfusion index (transplants)

References

1. Britton KE, Maisey MN, Hilson AJW. Renal Radionuclide Studies. Clinical Nuclear Medicine2nd Edition, 91-130
2. Diffey BL, Hall FM, Corfield JR. The 99mTc-DTPA dynamic renal scan with deconvolution analysis. J Nucl Med 1976; 17:352-355
3. Pedroso de Lima J.J. Nuclear Medicine and mathematics. Eur J Nucl Med1996; 23(6):705-719
4. Britton KE et al. Obstructive nephropathy: comparison between parenchymal transit time index and frusemide diuresis. Br J Urol 1987; 59(2):127-32
5. Britton KE. Obstructive nephropathy: successful evaluation with radionuclides. Lancet1979; 1:905-7
6. al-Nahhas A. Validity of the mean parenchymal transit time as a screening test for the detection of functional renal artery stenosis in hypertensive patients. Nucl Med Commun1989; 10(11):807-15
7. Hilson AJW, Maisey MN, Brown CB et al, Dynamic Renal Transplant Imaging with tc-99m-DTPA(Sn) supplemented by a transplant perfusion index in the management of renal transplants. J Nucl Med1978;19:9941000
8. Peters AM, Graphical analysis of dynamic data: the Patlak-Rutland plot. Nuc Med Commun1994;15:669-672
9. Piepsz A, et al. The robustness of the Patlak-Rutland slope for the determination of split renal function. Nuc Med. Commun1996;17:817-821
10. Moonen M, Granerus G. Subtraction of extra-renal background in 99mTc-DTPA renography: comparison of various regions of interest. Clin Physiol 1992;12:453-461
11. Prigent A et al. Consensus Report on Quality Control of Quantitative Measurements of Renal Function Obtained From the Renogram: International Consensus Committee From the cientific committee of Radionuclides in Nephrourology. : Seminars in Nucl Med1999;29:146-159

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